Unknown

Dataset Information

0

Efficacy and tolerability of telmisartan plus amlodipine in asian patients not adequately controlled on either monotherapy or on low-dose combination therapy.


ABSTRACT: Objective. To evaluate the efficacy and safety of the telmisartan plus amlodipine (T/A) single-pill combination (SPC) in Asian patients with hypertension whose blood pressure (BP) was not adequately controlled on either monotherapy or on low-dose combination therapy. Patients and Methods. Data are presented from five Boehringer Ingelheim-sponsored phase 3, double-blind, 8-week, studies: two studies in nonresponders to amlodipine (data pooled for amlodipine), two studies on nonresponders to telmisartan (pooled data), and one on nonresponders to low-dose T/A SPC. Results. After 8 weeks' treatment, mean reductions from the reference baseline in diastolic BP (DBP; primary endpoint), systolic BP (SBP), and SBP, DBP goal, and response rates were higher with the T/A SPC than respective monotherapies. The T80/A5 SPC resulted in greater reductions in DBP and SBP, and higher DBP goal and response rate than the low-dose T40/A5 SPC. Peripheral edema incidence was low (amlodipine 0.5%, telmisartan 0.0%, and T/A SPC 0.7%). Discussion and Conclusion. In Asian patients whose BP is not adequately controlled with telmisartan or amlodipine monotherapy, T/A SPC treatment results in greater BP reduction, and higher DBP and SBP goal and response rates. The safety and tolerability of the T/A SPC are comparable to those of the respective monotherapies and consistent with those reported in previous studies.

SUBMITTER: Zhu D 

PROVIDER: S-EPMC3955615 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

altmetric image

Publications

Efficacy and tolerability of telmisartan plus amlodipine in asian patients not adequately controlled on either monotherapy or on low-dose combination therapy.

Zhu Dingliang D   Gao Pingjin P   Yagi Nobutaka N   Schumacher Helmut H  

International journal of hypertension 20140227


Objective. To evaluate the efficacy and safety of the telmisartan plus amlodipine (T/A) single-pill combination (SPC) in Asian patients with hypertension whose blood pressure (BP) was not adequately controlled on either monotherapy or on low-dose combination therapy. Patients and Methods. Data are presented from five Boehringer Ingelheim-sponsored phase 3, double-blind, 8-week, studies: two studies in nonresponders to amlodipine (data pooled for amlodipine), two studies on nonresponders to telmi  ...[more]

Similar Datasets

| S-EPMC3703394 | biostudies-literature
| S-EPMC8886760 | biostudies-literature
| S-EPMC6011241 | biostudies-literature
| S-EPMC5857156 | biostudies-literature
| S-EPMC3219858 | biostudies-literature
| S-EPMC5125808 | biostudies-literature
| S-EPMC8108958 | biostudies-literature
| S-EPMC3606043 | biostudies-literature
| S-EPMC2963900 | biostudies-other
| S-EPMC5339800 | biostudies-literature