Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.
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ABSTRACT:
SUBMITTER: Smith AL
PROVIDER: S-EPMC3955700 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.
Smith Aaron L AL Freeman Sara M SM Voll Ronald J RJ Young Larry J LJ Goodman Mark M MM
Bioorganic & medicinal chemistry letters 20130730 19
The compound 1-(1-(2-(2-(2-fluoroethoxy)-4-(piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one (1) was synthesized and positively evaluated in vitro for high potency and selectivity with human oxytocin receptors. The positron emitting analogue, [F-18]1, was synthesized and investigated in vivo via PET imaging using rat and cynomolgus monkey models. PET imaging studies in female Sprague-Dawley rats suggested [F-18]1 reached the brain and accumulated in various regions o ...[more]
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