Ontology highlight
ABSTRACT:
SUBMITTER: Kuntz DA
PROVIDER: S-EPMC3956299 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20090101 2
Mannostatin A is a potent inhibitor of the mannose-trimming enzyme, Golgi alpha-mannosidase II (GMII), which acts late in the N-glycan processing pathway. Inhibition of this enzyme provides a route to blocking the transformation-associated changes in cancer cell surface oligosaccharide structures. Here, we report on the synthesis of new Mannostatin derivatives and analyze their binding in the active site of Drosophila GMII by X-ray crystallography. The results indicate that the interaction with ...[more]