Ontology highlight
ABSTRACT:
SUBMITTER: Owais M
PROVIDER: S-EPMC3956663 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Owais Mohammad M Kazmi Shadab S Tufail Saba S Zubair Swaleha S
PloS one 20140317 3
Bi-functional antibodies with the ability to bind two unrelated epitopes have remarkable potential in diagnostic and bio-sensing applications. In the present study, bispecific antibodies that recognize human red blood cell (RBC) and the food borne pathogen Listeria monocytogenes (L. monocytogenes) were engineered. The procedure involves initial reduction of a mixture of anti-RBC and anti-Listeria antibodies followed by gradual re-oxidation of the reduced disulphides. This facilitates association ...[more]