Ontology highlight
ABSTRACT:
SUBMITTER: Gras B
PROVIDER: S-EPMC3956896 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gras Baptiste B Jacqueroud Laurent L Wierinckx Anne A Lamblot Christelle C Fauvet Frédérique F Lachuer Joël J Puisieux Alain A Ansieau Stéphane S
PloS one 20140317 3
By fostering cell commitment to the epithelial-to-mesenchymal transition (EMT), SNAIL proteins endow cells with motility, thereby favoring the metastatic spread of tumor cells. Whether the phenotypic change additionally facilitates tumor initiation has never been addressed. Here we demonstrate that when a SNAIL protein is ectopically produced in non-transformed mammary epithelial cells, the cells are protected from anoikis and proliferate under low-adherence conditions: a hallmark of cancer cell ...[more]