Dataset Information
The association of serum ionized calcium and vitamin D with adult cognitive performance.
Ontology highlight
ABSTRACT: Background
High serum calcium levels have been associated with cognitive decline in older adults. These associations have not been studied in younger adults. The possible association of vitamin D with cognitive function, independent of calcium, is unknown.Methods
A cross-sectional study of associations of serum ionized calcium and 25-hydroxyvitamin D levels with cognitive function in younger adults (20-59 years) and older adults (60-90 years) was conducted using data from the US third National Health and Nutrition Examination Survey (NHANES III).Results
Neither serum ionized calcium nor 25-hydroxyvitamin D was associated with cognitive function in either age group. For example, the confounder-adjusted mean difference in reaction time in young adults was 0.00 (95% confidence interval = -0.07 to 0.06) per 1 SD calcium.Conclusion
Our results do not support an important role for calcium or vitamin D in cognitive performance in adults.
SUBMITTER: Tolppanen AM
PROVIDER: S-EPMC3957006 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
The association of serum ionized calcium and vitamin D with adult cognitive performance.
Epidemiology (Cambridge, Mass.) 20110101 1
<h4>Background</h4>High serum calcium levels have been associated with cognitive decline in older adults. These associations have not been studied in younger adults. The possible association of vitamin D with cognitive function, independent of calcium, is unknown.<h4>Methods</h4>A cross-sectional study of associations of serum ionized calcium and 25-hydroxyvitamin D levels with cognitive function in younger adults (20-59 years) and older adults (60-90 years) was conducted using data from the US ...[more]