A novel significance score for gene selection and ranking.
Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC3957066 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
A novel significance score for gene selection and ranking.
Xiao Yufei Y Hsiao Tzu-Hung TH Suresh Uthra U Chen Hung-I Harry HI Wu Xiaowu X Wolf Steven E SE Chen Yidong Y
Bioinformatics (Oxford, England) 20120209 6
<h4>Motivation</h4>When identifying differentially expressed (DE) genes from high-throughput gene expression measurements, we would like to take both statistical significance (such as P-value) and biological relevance (such as fold change) into consideration. In gene set enrichment analysis (GSEA), a score that can combine fold change and P-value together is needed for better gene ranking.<h4>Results</h4>We defined a gene significance score π-value by combining expression fold change and statist ...[more]
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