The exomer cargo adaptor features a flexible hinge domain.
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ABSTRACT:
SUBMITTER: Richardson BC
PROVIDER: S-EPMC3957094 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
The exomer cargo adaptor features a flexible hinge domain.
Richardson Brian C BC Fromme J Christopher JC
Structure (London, England : 1993) 20130207 3
Exomer is a cargo adaptor that mediates the sorting of specific plasma membrane proteins into vesicles at the trans-Golgi network. Cargo adaptors must bind to multiple partners, including their cargo, regulatory proteins, and the membrane surface. During biogenesis of a vesicle, the membrane makes a transition from a relatively flat surface to one of high curvature, requiring cargo adaptors to somehow maintain protein-protein and protein-membrane interactions on a changing membrane environment. ...[more]
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