Ontology highlight
ABSTRACT:
SUBMITTER: Reinert RB
PROVIDER: S-EPMC3957372 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Reinert Rachel B RB Cai Qing Q Hong Ji-Young JY Plank Jennifer L JL Aamodt Kristie K Prasad Nripesh N Aramandla Radhika R Dai Chunhua C Levy Shawn E SE Pozzi Ambra A Labosky Patricia A PA Wright Christopher V E CV Brissova Marcela M Powers Alvin C AC
Development (Cambridge, England) 20140226 7
Neurovascular alignment is a common anatomical feature of organs, but the mechanisms leading to this arrangement are incompletely understood. Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. In mature islets, nerves are closely associated with capillaries, but the islet vascularization process during embryonic organogenesis significantly precedes islet innervation. Although a simple neuronal me ...[more]