Predicting specificity in bZIP coiled-coil protein interactions.
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ABSTRACT:
SUBMITTER: Fong JH
PROVIDER: S-EPMC395749 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Publications
Predicting specificity in bZIP coiled-coil protein interactions.
Fong Jessica H JH Keating Amy E AE Singh Mona M
Genome biology 20040116 2
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach ...[more]
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