Ontology highlight
ABSTRACT:
SUBMITTER: Genois MM
PROVIDER: S-EPMC3957735 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Microbiology and molecular biology reviews : MMBR 20140301 1
All living organisms are continuously faced with endogenous or exogenous stress conditions affecting genome stability. DNA repair pathways act as a defense mechanism, which is essential to maintain DNA integrity. There is much to learn about the regulation and functions of these mechanisms, not only in human cells but also equally in divergent organisms. In trypanosomatids, DNA repair pathways protect the genome against mutations but also act as an adaptive mechanism to promote drug resistance. ...[more]