VanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.
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ABSTRACT:
SUBMITTER: Gudeta DD
PROVIDER: S-EPMC3957834 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.
Gudeta Dereje Dadi DD Moodley Arshnee A Bortolaia Valeria V Guardabassi Luca L
Antimicrobial agents and chemotherapy 20131216 3
We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical ...[more]
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