Ontology highlight
ABSTRACT:
SUBMITTER: Schafer C
PROVIDER: S-EPMC3957878 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Schäfer Carola C Tejera Nevado Paloma P Zander Dorothea D Clos Joachim J
Antimicrobial agents and chemotherapy 20131223 3
Antimony-based drugs are still the mainstay of chemotherapy against Leishmania infections in many countries where the parasites are endemic. The efficacy of antimonials has been compromised by increasing numbers of resistant infections, the basis of which is not fully understood and likely involves multiple factors. By using a functional cloning strategy, we recently identified a novel antimony resistance marker, ARM58, from the parasite Leishmania braziliensis that protects the parasites agains ...[more]