Enriching for direct regulatory targets in perturbed gene-expression profiles.
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ABSTRACT:
SUBMITTER: Tringe SG
PROVIDER: S-EPMC395788 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Publications
Enriching for direct regulatory targets in perturbed gene-expression profiles.
Tringe Susannah G SG Wagner Andreas A Ruby Stephanie W SW
Genome biology 20040330 4
Here we build on a previously proposed algorithm to infer direct regulatory relationships using gene-expression profiles from cells in which individual genes are deleted or overexpressed. The updated algorithm can process networks containing feedback loops, incorporate positive and negative regulatory relationships during network reconstruction, and utilize data from double mutants to resolve ambiguous regulatory relationships. When applied to experimental data the reconstruction procedure prefe ...[more]
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