Murine gammaherpesvirus 68 encodes a second PML-modifying protein.
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ABSTRACT:
SUBMITTER: Sewatanon J
PROVIDER: S-EPMC3957941 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Murine gammaherpesvirus 68 encodes a second PML-modifying protein.
Sewatanon Jaturong J Ling Paul D PD
Journal of virology 20131226 6
The ORF75c tegument protein of murine gammaherpesvirus 68 (MHV68) promotes the degradation of the antiviral promyelocytic leukemia (PML) protein. Surprisingly, MHV68 expressing a degradation-deficient ORF75c replicated in cell culture and in mice similar to the wild-type virus. However, in cells infected with this mutant virus, PML formed novel track-like structures that are induced by ORF61, the viral ribonucleotide reductase large subunit. These findings may explain why ORF75c mutant viruses u ...[more]
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