Ontology highlight
ABSTRACT:
SUBMITTER: Fuzesi-Levi MG
PROVIDER: S-EPMC3958043 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Füzesi-Levi Maria G MG Ben-Nissan Gili G Bianchi Elisabetta E Zhou Houjiang H Deery Michael J MJ Lilley Kathryn S KS Levin Yishai Y Sharon Michal M
Molecular and cellular biology 20140113 6
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that participates in the regulation of the ubiquitin/26S proteasome pathway by controlling the function of cullin-RING-ubiquitin ligases. Impressive progress has been made in deciphering its critical role in diverse cellular and developmental processes. However, little is known about the underlying regulatory principles that coordinate its function. Through biochemical and fluorescence microscopy analyses, we determined th ...[more]