Cancer-risk module identification and module-based disease risk evaluation: a case study on lung cancer.
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ABSTRACT:
SUBMITTER: Jia X
PROVIDER: S-EPMC3958511 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Cancer-risk module identification and module-based disease risk evaluation: a case study on lung cancer.
Jia Xu X Miao Zhengqiang Z Li Wan W Zhang Liangcai L Feng Chenchen C He Yuehan Y Bi Xiaoman X Wang Liqiang L Du Youwen Y Hou Min M Hao Dapeng D Xiao Yun Y Chen Lina L Li Kongning K
PloS one 20140318 3
Gene expression profiles have drawn broad attention in deciphering the pathogenesis of human cancers. Cancer-related gene modules could be identified in co-expression networks and be applied to facilitate cancer research and clinical diagnosis. In this paper, a new method was proposed to identify lung cancer-risk modules and evaluate the module-based disease risks of samples. The results showed that thirty one cancer-risk modules were closely related to the lung cancer genes at the functional le ...[more]
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