Ontology highlight
ABSTRACT:
SUBMITTER: Payne AJ
PROVIDER: S-EPMC3958826 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Payne Andrew J AJ Kaja Simon S Naumchuk Yuliya Y Kunjukunju Nancy N Koulen Peter P
International journal of molecular sciences 20140127 2
The molecular pathways contributing to visual signal transduction in the retina generate a high energy demand that has functional and structural consequences such as vascularization and high metabolic rates contributing to oxidative stress. Multiple signaling cascades are involved to actively regulate the redox state of the retina. Age-related processes increase the oxidative load, resulting in chronically elevated levels of oxidative stress and reactive oxygen species, which in the retina ultim ...[more]