Ontology highlight
ABSTRACT:
SUBMITTER: Vaidya SP
PROVIDER: S-EPMC3958963 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Nature neuroscience 20131103 12
Timing is a crucial aspect of synaptic integration. For pyramidal neurons that integrate thousands of synaptic inputs spread across hundreds of microns, it is thus a challenge to maintain the timing of incoming inputs at the axo-somatic integration site. Here we show that pyramidal neurons in the rodent hippocampus use a gradient of inductance in the form of hyperpolarization-activated cation-nonselective (HCN) channels as an active mechanism to counteract location-dependent temporal differences ...[more]