Ontology highlight
ABSTRACT:
SUBMITTER: Ohanian M
PROVIDER: S-EPMC3959284 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Ohanian Maro M Kantarjian Hagop M HM Quintas-Cardama Alfonso A Jabbour Elias E Abruzzo Lynne L Verstovsek Srdan S Borthakur Gautam G Ravandi Farhad F Garcia-Manero Guillermo G Champlin Richard R Pierce Sherry S Alattar Mona Lisa ML Trinh Long Xuan LX Luthra Raja R Ferrajoli Alessandra A Kadia Tapan T O'Brien Susan S Cortes Jorge E JE
Clinical lymphoma, myeloma & leukemia 20131209 2
<h4>Background</h4>Accelerated phase CML most frequently represents a progression state in CML. However, some patients present with AP features at the time of diagnosis. There is limited information on the outcome of these patients who received TKIs as initial therapy.<h4>Patients and methods</h4>We analyzed the outcome of 51 consecutive patients with CML who presented with features of AP at the time of diagnosis, including blasts ≥ 15% (n = 6), basophils ≥ 20% (n = 22), platelets < 100 × 10(9)/ ...[more]