Ontology highlight
ABSTRACT:
SUBMITTER: Fogh I
PROVIDER: S-EPMC3959809 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Fogh Isabella I Ratti Antonia A Gellera Cinzia C Lin Kuang K Tiloca Cinzia C Moskvina Valentina V Corrado Lucia L Sorarù Gianni G Cereda Cristina C Corti Stefania S Gentilini Davide D Calini Daniela D Castellotti Barbara B Mazzini Letizia L Querin Giorgia G Gagliardi Stella S Del Bo Roberto R Conforti Francesca L FL Siciliano Gabriele G Inghilleri Maurizio M Saccà Francesco F Bongioanni Paolo P Penco Silvana S Corbo Massimo M Sorbi Sandro S Filosto Massimiliano M Ferlini Alessandra A Di Blasio Anna M AM Signorini Stefano S Shatunov Aleksey A Jones Ashley A Shaw Pamela J PJ Morrison Karen E KE Farmer Anne E AE Van Damme Philip P Robberecht Wim W Chiò Adriano A Traynor Bryan J BJ Sendtner Michael M Melki Judith J Meininger Vincent V Hardiman Orla O Andersen Peter M PM Leigh Nigel P NP Glass Jonathan D JD Overste Daniel D Diekstra Frank P FP Veldink Jan H JH van Es Michael A MA Shaw Christopher E CE Weale Michael E ME Lewis Cathryn M CM Williams Julie J Brown Robert H RH Landers John E JE Ticozzi Nicola N Ceroni Mauro M Pegoraro Elena E Comi Giacomo P GP D'Alfonso Sandra S van den Berg Leonard H LH Taroni Franco F Al-Chalabi Ammar A Powell John J Silani Vincenzo V
Human molecular genetics 20131120 8
Identification of mutations at familial loci for amyotrophic lateral sclerosis (ALS) has provided novel insights into the aetiology of this rapidly progressing fatal neurodegenerative disease. However, genome-wide association studies (GWAS) of the more common (∼90%) sporadic form have been less successful with the exception of the replicated locus at 9p21.2. To identify new loci associated with disease susceptibility, we have established the largest association study in ALS to date and undertake ...[more]