Ontology highlight
ABSTRACT:
SUBMITTER: Siracusa MC
PROVIDER: S-EPMC3959827 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Siracusa Mark C MC Saenz Steven A SA Wojno Elia D Tait ED Kim Brian S BS Osborne Lisa C LC Ziegler Carly G CG Benitez Alain J AJ Ruymann Kathryn R KR Farber Donna L DL Sleiman Patrick M PM Hakonarson Hakon H Cianferoni Antonella A Wang Mei-Lun ML Spergel Jonathan M JM Comeau Michael R MR Artis David D
Immunity 20131201 6
Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern-recognition receptor (PRR)-expressing HSCs, EMH, and immune responses to microbial stimuli. However, whether EMH operates in broader immune contexts remains unknown. Here, we demonstrate a previously unrecognized role for thymic stromal lymphopoietin (TSLP) in promoting the population expans ...[more]