Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3959860 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Yang Yanzhong Y McBride Kevin M KM Hensley Sean S Lu Yue Y Chedin Frederic F Bedford Mark T MT
Molecular cell 20140201 3
Tudor domain-containing protein 3 (TDRD3) is a major methylarginine effector molecule that reads methyl-histone marks and facilitates gene transcription. However, the underlying mechanism by which TDRD3 functions as a transcriptional coactivator is unknown. We identified topoisomerase IIIB (TOP3B) as a component of the TDRD3 complex. TDRD3 serves as a molecular bridge between TOP3B and arginine-methylated histones. The TDRD3-TOP3B complex is recruited to the c-MYC gene promoter primarily by the ...[more]