Ontology highlight
ABSTRACT:
SUBMITTER: Lin YC
PROVIDER: S-EPMC3960210 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Lin Yu-Chin YC Wu Meng-Hsuan MH Wei Tzu-Tang TT Lin Yun-Chieh YC Huang Wen-Chih WC Huang Liang-Yu LY Lin Yi-Ting YT Chen Ching-Chow CC
Oncotarget 20140101 1
Head and neck squamous cell carcinoma (HNSCC) is an important endemic disease in Taiwan with aggressive course and dismal outcome. Dasatinib is a Bcr-bl and Src kinase inhibitor that has potential against HNSCC. We recently disclosed that EGFR degradation is critical for dasatinib-induced apoptosis. Here, we further demonstrate that AMPK-dependent ER stress is responsible for this event. Dasatinib induced ER stress which mediated EGFR degradation in a c-cbl-dependent manner. AMPK activation indu ...[more]