Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum.

ABSTRACT:

Objectives

To examine regions of cortical thinning and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers associated with apathy and hallucinations in a continuum of individuals including clinically normal elderly, mild cognitive impairment, and mild AD dementia.

Design

Cross-sectional and longitudinal studies.

Setting

Fifty-seven research sites across North America.

Participants

Eight-hundred twelve community-dwelling volunteers; 413 participants in the CSF sub-study.

Measurements

Structural magnetic resonance imaging data and CSF concentrations of amyloid-β 1-42, total tau, and phosphorylated tau derived from the Alzheimer Disease Neuroimaging Initiative database were analyzed. Apathy and hallucinations were measured at baseline and over 3 yea

SUBMITTER: Donovan NJ 

PROVIDER: S-EPMC3960369 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature