Ontology highlight
ABSTRACT:
SUBMITTER: Musille PM
PROVIDER: S-EPMC3960984 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Musille Paul M PM Pathak Manish M Lauer Janelle L JL Hudson William H WH Griffin Patrick R PR Ortlund Eric A EA
Nature structural & molecular biology 20120415 5
The human nuclear receptor liver receptor homolog-1 (LRH-1) has an important role in controlling lipid and cholesterol homeostasis and is a potential target for the treatment of diabetes and hepatic diseases. LRH-1 is known to bind phospholipids, but the role of phospholipids in controlling LRH-1 activation remains highly debated. Here we describe the structure of both apo LRH-1 and LRH-1 in complex with the antidiabetic phospholipid dilauroylphosphatidylcholine (DLPC). Together with hydrogen-de ...[more]