Bile acids activate YAP to promote liver carcinogenesis.
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ABSTRACT:
SUBMITTER: Anakk S
PROVIDER: S-EPMC3961013 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Bile acids activate YAP to promote liver carcinogenesis.
Anakk Sayeepriyadarshini S Bhosale Manoj M Schmidt Valentina A VA Johnson Randy L RL Finegold Milton J MJ Moore David D DD
Cell reports 20131121 4
Elevated bile acid levels increase hepatocellular carcinoma by unknown mechanisms. Here, we show that mice with a severe defect in bile acid homeostasis due to the loss of the nuclear receptors FXR and SHP have enlarged livers, progenitor cell proliferation, and Yes-associated protein (YAP) activation and develop spontaneous liver tumorigenesis. This phenotype mirrors mice with loss of hippo kinases or overexpression of their downstream target, YAP. Bile acids act as upstream regulators of YAP v ...[more]
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