Dataset Information

Effect of dopamine therapy on nonverbal affect burst recognition in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) provides a model for investigating the involvement of the basal ganglia and mesolimbic dopaminergic system in the recognition of emotions from voices (i.e., emotional prosody). Although previous studies of emotional prosody recognition in PD have reported evidence of impairment, none of them compared PD patients at different stages of the disease, or ON and OFF dopamine replacement therapy, making it difficult to determine whether their impairment was due to general cognitive deterioration or to a more specific dopaminergic deficit.

Methods

We explored the involvement of the dopaminergic pathways in the recognition of nonverbal affect bursts (onomatopoeias) in 15 newly diagnosed PD patients in the early stages of the disease, 15 PD patients in the advanced stages of the disease and 15 healthy controls. The early PD group was studied in two conditions: ON and OFF dopaminergic therapy.

Results

Results showed that the early PD patients performed more poorly in the ON condition than in the OFF one, for overall emotion recognition, as well as for the recognition of anger, disgust and fear. Additionally, for anger, the early PD ON patients performed more poorly than controls. For overall emotion recognition, both advanced PD patients and early PD ON patients performed more poorly than controls. Analysis of continuous ratings on target and nontarget visual analog scales confirmed these patterns of results, showing a systematic emotional bias in both the advanced PD and early PD ON (but not OFF) patients compared with controls.

Conclusions

These results i) confirm the involvement of the dopaminergic pathways and basal ganglia in emotional prosody recognition, and ii) suggest a possibly deleterious effect of dopatherapy on affective abilities in the early stages of PD.

SUBMITTER: Peron J

PROVIDER: S-EPMC3961247 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Effect of dopamine therapy on nonverbal affect burst recognition in Parkinson's disease.

Péron Julie J Grandjean Didier D Drapier Sophie S Vérin Marc M

PloS one 20140320 3

<h4>Background</h4>Parkinson's disease (PD) provides a model for investigating the involvement of the basal ganglia and mesolimbic dopaminergic system in the recognition of emotions from voices (i.e., emotional prosody). Although previous studies of emotional prosody recognition in PD have reported evidence of impairment, none of them compared PD patients at different stages of the disease, or ON and OFF dopamine replacement therapy, making it difficult to determine whether their impairment was ...[more]

PMID: 24651759

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Dataset Information

Effect of dopamine therapy on nonverbal affect burst recognition in Parkinson's disease.

Background

Methods

Results

Conclusions

Publications

Effect of dopamine therapy on nonverbal affect burst recognition in Parkinson's disease.

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