Ontology highlight
ABSTRACT:
SUBMITTER: Yao Z
PROVIDER: S-EPMC3961566 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Yao Zhenqiang Z Li Yanyun Y Yin Xiaoxiang X Dong Yufeng Y Xing Lianping L Boyce Brendan F BF
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20140401 4
RelA-mediated NF-κB canonical signaling promotes mesenchymal progenitor cell (MPC) proliferation, but inhibits differentiation of mature osteoblasts (OBs) and thus negatively regulates bone formation. Previous studies suggest that NF-κB RelB may also negatively regulate bone formation through noncanonical signaling, but they involved a complex knockout mouse model, and the molecular mechanisms involved were not investigated. Here, we report that RelB(-/-) mice develop age-related increased trabe ...[more]