Ontology highlight
ABSTRACT:
SUBMITTER: Sethi R
PROVIDER: S-EPMC3961682 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Sethi Ritika R Seppälä Jonne J Tossavainen Helena H Ylilauri Mikko M Ruskamo Salla S Pentikäinen Olli T OT Pentikäinen Ulla U Permi Perttu P Ylänne Jari J
The Journal of biological chemistry 20140127 12
Immunoglobulin-like (Ig) domains are a widely expanded superfamily that act as interaction motifs or as structural spacers in multidomain proteins. Vertebrate filamins (FLNs), which are multifunctional actin-binding proteins, consist of 24 Ig domains. We have recently discovered that in the C-terminal rod 2 region of FLN, Ig domains interact with each other forming functional domain pairs, where the interaction with signaling and transmembrane proteins is mechanically regulated by weak actomyosi ...[more]