Ontology highlight
ABSTRACT:
SUBMITTER: Jiang W
PROVIDER: S-EPMC3962309 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Jiang Wenqing W Wang Shiwen S Xiao Mengtao M Lin Yan Y Zhou Lisha L Lei Qunying Q Xiong Yue Y Guan Kun-Liang KL Zhao Shimin S
Molecular cell 20110701 1
Protein acetylation has emerged as a major mechanism in regulating cellular metabolism. Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is irreversible, and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis. Here, we show that acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1, thereby modulating cellular response to glucose. High glucose destabilizes PEPCK1 by stimulati ...[more]