Ontology highlight
ABSTRACT:
SUBMITTER: Dogar AM
PROVIDER: S-EPMC3962651 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Dogar Afzal M AM Semplicio Giuseppe G Guennewig Boris B Hall Jonathan J
Nucleic acid therapeutics 20140120 2
Thrombospondin 1 (THBS1) is a secreted protein with a variety of biological functions, including a potent anti-angiogenic activity and activation of latent transforming growth factor beta (TGF-β). In many human cancers it is expressed at low levels, although mutations in the THBS1 gene have been rarely reported. Instead, the loss of THBS1 expression has been proposed to be due to transcriptional and post-transcriptional deregulations. In a systematic screen of predicted microRNA (miRNA) binding ...[more]