A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy.
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ABSTRACT:
SUBMITTER: Patel HK
PROVIDER: S-EPMC3962780 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy.
Patel Hitisha K HK Siklos Marton I MI Abdelkarim Hazem H Mendonca Emma L EL Vaidya Aditya A Petukhov Pavel A PA Thatcher Gregory R J GR
ChemMedChem 20130816 3
Breast cancer remains a significant cause of death in women, and few therapeutic options exist for estrogen receptor negative (ER (-)) cancers. Epigenetic reactivation of target genes using histone deacetylase (HDAC) inhibitors has been proposed in ER (-) cancers to resensitize to therapy using selective estrogen receptor modulators (SERMs) that are effective in ER (+) cancer treatment. Based upon preliminary studies in ER (+) and ER (-) breast cancer cells treated with combinations of HDAC inhi ...[more]
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