Ontology highlight
ABSTRACT:
SUBMITTER: Roh-Johnson M
PROVIDER: S-EPMC3962803 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Roh-Johnson M M Bravo-Cordero J J JJ Patsialou A A Sharma V P VP Guo P P Liu H H Hodgson L L Condeelis J J
Oncogene 20130923 33
Most cancer patients die as a result of metastasis, thus it is important to understand the molecular mechanisms of dissemination, including intra- and extravasation. Although the mechanisms of extravasation have been vastly studied in vitro and in vivo, the process of intravasation is still unclear. Furthermore, how cells in the tumor microenvironment facilitate tumor cell intravasation is still unknown. Using high-resolution imaging, we found that macrophages enhance tumor cell intravasation up ...[more]