Ontology highlight
ABSTRACT:
SUBMITTER: Dumont M
PROVIDER: S-EPMC3963016 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Dumont Magali M Stack Cliona C Elipenahli Ceyhan C Jainuddin Shari S Launay Nathalie N Gerges Meri M Starkova Natalia N Starkov Anatoly A AA Calingasan Noel Y NY Tampellini Davide D Pujol Aurora A Beal M Flint MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140107 4
The peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) interacts with various transcription factors involved in energy metabolism and in the regulation of mitochondrial biogenesis. PGC-1α mRNA levels are reduced in a number of neurodegenerative diseases and contribute to disease pathogenesis, since increased levels ameliorate behavioral defects and neuropathology of Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis. PGC-1α and its downstream targets ...[more]