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Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.

ABSTRACT: Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity.

SUBMITTER: Kusuma BR

PROVIDER: S-EPMC3963410 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.

Kusuma Bhaskar Reddy BR Khandelwal Anuj A Gu Wen W Brown Douglas D Liu Weiya W Vielhauer George G Holzbeierlein Jeffrey J Blagg Brian S J BS

Bioorganic & medicinal chemistry 20140103 4

Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests ...[more]

PMID: 24461493

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