Ontology highlight
ABSTRACT:
SUBMITTER: Kusuma BR
PROVIDER: S-EPMC3963410 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20140103 4
Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests ...[more]