Ontology highlight
ABSTRACT:
SUBMITTER: Fan Q
PROVIDER: S-EPMC3963525 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Fan Qipeng Q Gu Dongsheng D Liu Hailan H Yang Ling L Zhang Xiaoli X Yoder Mervin C MC Kaplan Mark H MH Xie Jingwu J
Cancer research 20131126 2
Hedgehog signaling in cancer cells drives changes in the tumor microenvironment that are incompletely understood. Here, we report that hedgehog-driven tumors exhibit an increase in myeloid-derived suppressor cells (MDSC) and a decrease in T cells, indicative of an immunosuppressive tumor microenvironment. This change was associated with activated TGF-β signaling in several cell types in basal cell carcinomas. We determined that TGF-β signaling in bone marrow-derived cells, not keratinocytes, reg ...[more]