Ontology highlight
ABSTRACT:
SUBMITTER: Winkler EA
PROVIDER: S-EPMC3964055 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Winkler Ethan A EA Sengillo Jesse D JD Sagare Abhay P AP Zhao Zhen Z Ma Qingyi Q Zuniga Edward E Wang Yaoming Y Zhong Zhihui Z Sullivan John S JS Griffin John H JH Cleveland Don W DW Zlokovic Berislav V BV
Proceedings of the National Academy of Sciences of the United States of America 20140303 11
Humans with ALS and transgenic rodents expressing ALS-associated superoxide dismutase (SOD1) mutations develop spontaneous blood-spinal cord barrier (BSCB) breakdown, causing microvascular spinal-cord lesions. The role of BSCB breakdown in ALS disease pathogenesis in humans and mice remains, however, unclear, although chronic blood-brain barrier opening has been shown to facilitate accumulation of toxic blood-derived products in the central nervous system, resulting in secondary neurodegenerativ ...[more]