Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.
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ABSTRACT:
SUBMITTER: Bramhall NF
PROVIDER: S-EPMC3964281 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.
Bramhall Naomi F NF Shi Fuxin F Arnold Katrin K Hochedlinger Konrad K Edge Albert S B AS
Stem cell reports 20140220 3
The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound. Here, we show that supporting cells, which surround hair cells in the normal cochlear epithelium, differentiate into new hair cells in the neonatal mouse following ototoxic damage. Using lineage tracing, we show that new hair cells, predominantly outer hair cells, arise from Lgr5-expressing inner pillar and thir ...[more]
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