The genomes of four tapeworm species reveal adaptations to parasitism.
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ABSTRACT:
SUBMITTER: Tsai IJ
PROVIDER: S-EPMC3964345 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
The genomes of four tapeworm species reveal adaptations to parasitism.
Tsai Isheng J IJ Zarowiecki Magdalena M Holroyd Nancy N Garciarrubio Alejandro A Sánchez-Flores Alejandro A Brooks Karen L KL Tracey Alan A Bobes Raúl J RJ Fragoso Gladis G Sciutto Edda E Aslett Martin M Beasley Helen H Bennett Hayley M HM Cai Xuepeng X Camicia Federico F Clark Richard R Cucher Marcela M De Silva Nishadi N Day Tim A TA Deplazes Peter P Estrada Karel K Fernández Cecilia C Holland Peter W H PWH Hou Junling J Hu Songnian S Huckvale Thomas T Hung Stacy S SS Kamenetzky Laura L Keane Jacqueline A JA Kiss Ferenc F Koziol Uriel U Lambert Olivia O Liu Kan K Luo Xuenong X Luo Yingfeng Y Macchiaroli Natalia N Nichol Sarah S Paps Jordi J Parkinson John J Pouchkina-Stantcheva Natasha N Riddiford Nick N Rosenzvit Mara M Salinas Gustavo G Wasmuth James D JD Zamanian Mostafa M Zheng Yadong Y Cai Jianping J Soberón Xavier X Olson Peter D PD Laclette Juan P JP Brehm Klaus K Berriman Matthew M
Nature 20130313 7443
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115- to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of g ...[more]
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