Ontology highlight
ABSTRACT:
SUBMITTER: Huigens RW
PROVIDER: S-EPMC3965367 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Nature chemistry 20130120 3
High-throughput screening is the dominant method used to identify lead compounds in drug discovery. As such, the makeup of screening libraries largely dictates the biological targets that can be modulated and the therapeutics that can be developed. Unfortunately, most compound-screening collections consist principally of planar molecules with little structural or stereochemical complexity, compounds that do not offer the arrangement of chemical functionality necessary for the modulation of many ...[more]