Ontology highlight
ABSTRACT:
SUBMITTER: Klinkhammer BM
PROVIDER: S-EPMC3965415 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Klinkhammer Barbara Mara BM Kramann Rafael R Mallau Monika M Makowska Anna A van Roeyen Claudia Renate CR Rong Song S Buecher Eva Bettina EB Boor Peter P Kovacova Katarina K Zok Stephanie S Denecke Bernd B Stuettgen Esther E Otten Simon S Floege Juergen J Kunter Uta U
PloS one 20140325 3
Mesenchymal stem cell (MSC) transplantation has the potential for organ repair. Nevertheless, some factors might lessen the regenerative potential of MSCs, e.g. donor age or systemic disease. It is thus important to carefully assess the patient's suitability for autologous MSC transplantation. Here we investigated the effects of chronic kidney disease (CKD) on MSC function. We isolated bone marrow MSCs from remnant kidney rats (RK) with CKD (CKD-RK-MSC) and found signs of premature senescence: s ...[more]