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FDA's nozzle numerical simulation challenge: non-Newtonian fluid effects and blood damage.

ABSTRACT: Data from FDA's nozzle challenge-a study to assess the suitability of simulating fluid flow in an idealized medical device-is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from three different laboratories, getting a very good agreement. Special care is taken with the derivation of blood damage (hemolysis). The paper is focused on the laminar regime, in order to investigate non-Newtonian effects (non-constant fluid viscosity). The code can deal with these effects with just a small extra computational cost, improving Newtonian estimations up to a ten percent. The relevance of non-Newtonian effects for hemolysis parameters is discussed.

SUBMITTER: Trias M

PROVIDER: S-EPMC3965442 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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FDA's nozzle numerical simulation challenge: non-Newtonian fluid effects and blood damage.

Trias Miquel M Arbona Antonio A Massó Joan J Miñano Borja B Bona Carles C

PloS one 20140325 3

Data from FDA's nozzle challenge-a study to assess the suitability of simulating fluid flow in an idealized medical device-is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from three different laboratories, getting a very good agreement. Special care is taken with the derivation of blood damage (hemolysis). The paper is focused on the laminar regime, in order to investigate no ...[more]

PMID: 24667931

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