Ontology highlight
ABSTRACT: ConclusionsThe analysis reconfirmed two known GWAS loci (GCK, HK1) and identified 25 suggestive loci including one reconfirmed variant in G6PC2 and one replicated variant near OR10R3P/SPTA1. Future focused survey of sequence elements containing mainly functional and regulatory variants may yield additional findings.Objective
Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.Methods
A total of 4088 non-diabetic subjects from the LLFS were used for GWAS discoveries, and a total of 8231 non-diabetic subjects from the Atherosclerosis Risk in Communities Study (ARIC, in the MAGIC Consortium) and the Health, Aging, and Body Composition Study (HABC) were used for GWAS replications. HbA1c was adjusted for age, sex, centers, 20 principal components, without and with BMI. A linear mixed effects model was used for association testing.Results
Two known loci at GCK rs730497 (or rs2908282) and HK1 rs17476364 were confirmed (p<5e-8). Of 25 suggestive (5e-8
SUBMITTER: An P
PROVIDER: S-EPMC3965585 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
An Ping P Miljkovic Iva I Thyagarajan Bharat B Kraja Aldi T AT Daw E Warwick EW Pankow James S JS Selvin Elizabeth E Kao W H Linda WH Maruthur Nisa M NM Nalls Micahel A MA Liu Yongmei Y Harris Tamara B TB Lee Joseph H JH Borecki Ingrid B IB Christensen Kaare K Eckfeldt John H JH Mayeux Richard R Perls Thomas T TT Newman Anne B AB Province Michael A MA
Metabolism: clinical and experimental 20131204 4
<h4>Objective</h4>Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional ...[more]