Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3966049 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Wang Yejun Y Maharana Shovamayee S Wang Michelle D MD Shivashankar G V GV
Scientific reports 20140326
Remodeling of the local chromatin structure is essential for the regulation of gene expression. While a number of biochemical and bioimaging experiments suggest decondensed chromatin structures are associated with transcription, a direct visualization of DNA and transcriptionally active RNA polymerase II (RNA pol II) at super-resolution is still lacking. Here we investigate the structure of chromatin isolated from HeLa cells using binding activatable localization microscopy (BALM). The sample pr ...[more]