Ontology highlight
ABSTRACT:
SUBMITTER: Pont AR
PROVIDER: S-EPMC3966316 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Pont Adam R AR Sadri Navid N Hsiao Susan J SJ Smith Susan S Schneider Robert J RJ
Molecular cell 20120524 1
Inflammation is associated with DNA damage, cellular senescence, and aging. Cessation of the inflammatory cytokine response is mediated in part through cytokine mRNA degradation facilitated by RNA-binding proteins, including AUF1. We report a major function of AUF1-it activates telomerase expression, suppresses cellular senescence, and maintains normal aging. AUF1-deficient mice undergo striking telomere erosion, markedly increased DNA damage responses at telomere ends, pronounced cellular senes ...[more]