Ontology highlight
ABSTRACT:
SUBMITTER: Arumugam T
PROVIDER: S-EPMC3966516 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Arumugam Thiruvengadam T Ramachandran Vijaya V Sun Duoli D Peng Zhenghong Z Pal Ashutosh A Maxwell David S DS Bornmann William G WG Logsdon Craig D CD
Molecular cancer therapeutics 20130109 5
We have previously shown that the antiallergic drug cromolyn blocks S100P interaction with its receptor receptor for advanced glycation end product (RAGE) and improves gemcitabine effectiveness in pancreatic ductal adenocarcinoma (PDAC). However, the concentration required to achieve its effectiveness was high (100 μmol/L). In this study, we designed and synthesized analogs of cromolyn and analyzed their effectiveness compared with the parent molecule. An ELISA was used to confirm the binding of ...[more]