BRCA1 is a novel regulator of metabolic function in skeletal muscle.
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ABSTRACT:
SUBMITTER: Jackson KC
PROVIDER: S-EPMC3966701 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
BRCA1 is a novel regulator of metabolic function in skeletal muscle.
Jackson Kathryn C KC Gidlund Eva-Karin EK Norrbom Jessica J Valencia Ana P AP Thomson David M DM Schuh Rosemary A RA Neufer P Darrell PD Spangenburg Espen E EE
Journal of lipid research 20140224 4
Breast cancer type 1 (BRCA1) susceptibility protein is expressed across multiple tissues including skeletal muscle. The overall objective of this investigation was to define a functional role for BRCA1 in skeletal muscle using a translational approach. For the first time in both mice and humans, we identified the presence of multiple isoforms of BRCA1 in skeletal muscle. In response to an acute bout of exercise, we found increases in the interaction between the native forms of BRCA1 and the phos ...[more]
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