Ontology highlight
ABSTRACT:
SUBMITTER: Pauter AM
PROVIDER: S-EPMC3966705 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Pauter Anna M AM Olsson Petter P Asadi Abolfazl A Herslöf Bengt B Csikasz Robert I RI Zadravec Damir D Jacobsson Anders A
Journal of lipid research 20140131 4
The potential role of endogenously synthesized PUFAs is a highly overlooked area. Elongation of very long-chain fatty acids (ELOVLs) in mammals is catalyzed by the ELOVL enzymes to which the PUFA elongase ELOVL2 belongs. To determine its in vivo function, we have investigated how ablation of ELOVL2, which is highly expressed in liver, affects hepatic lipid composition and function in mice. The Elovl2(-/-) mice displayed substantially decreased levels of 22:6(n-3), DHA, and 22:5(n-6), docosapenta ...[more]