Ontology highlight
ABSTRACT:
SUBMITTER: Hu C
PROVIDER: S-EPMC3966877 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Hu Changlong C Rusin Craig G CG Tan Zhiyong Z Guagliardo Nick A NA Barrett Paula Q PQ
The Journal of clinical investigation 20120501 6
Aldosterone, which plays a central role in the regulation of blood pressure, is produced by zona glomerulosa (ZG) cells of the adrenal gland. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease. Although sustained production of aldosterone requires persistent Ca2+ entry through low-voltage activated Ca2+ channels, isolated ZG cells are considered nonexcitabl ...[more]